- Great Dane Rescue
 - Nonprofit organisation dedicated to the rescue and placement of unwanted/neglected Great Danes. Also offers education on the importance of spay/neuter and responsible pet ownership. - Harlequin Haven
- Protects homeless, abandoned, and mistreated Great Danes and other animals as space allows.
- Great Dane Rescue Connection
- Serves the surrounding Dallas/Ft. Worth area.
- Great Dane Rescue of Ohio
- Offering rescue, adoption, and health information for Great Danes.
- Rocky Mountain Great Dane Rescue, Inc.
- Group of volunteers concerned with finding new, permanent, and loving homes for Great Danes that have been abused, neglected, or abandoned in Colorado.
- Daneline
- Rescues, fosters, and rehouses Great Danes in the U.K.
- Great Dane Club Of Las Vegas
- Dedicated to the rescue, education, care, and love of Great Danes.
- Great Dane Assistance League, Inc.
- Group dedicated to the advancement of the Great Dane breed with respect to proper medical care, socialization, education, and ownership.
- Dane T.R.A.I.N.
- Group of volunteers who are willing to transport Great Danes, Dane mixes, and on occasion honorary Danes from shelters and other neglectful situations into rescues and forever homes across most of the U.S.
- Olympic Great Dane Rescue of Clallam County, WA
- For anyone seeking assistance for, or the rescue of, a Great Dane. Offers sheltering and adoption of rescued animals.
- Southern Indiana Great Dane Rescue
- Works directly with area animal control and local shelters to expedite placement of Great Danes into rescue foster homes where they will be safe until their forever home is found.
- Great Dane Angel Network
- Rescue organisation for Great Danes in Texas by volunteers who love the breed.
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